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Callie and Arizona have to make a choice regarding surrogacy while the board has to decide whether to give Cristina's seat on the board to Alex or Bailey. Amelia overhears the truth about Maggie Pierce.
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The doctors from Grey Sloan Memorial Hospital spring into action to save the lives of two girls with a powerful story. Meanwhile, Meredith tries to cope with the fact that Amelia is now living with her and Jackson prepares for April's return back to Seattle.
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本剧故事基于Al Ruddy在电影《教父》中从未公开的制片经历创作。
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白人公司职员克里斯·马特森（帕特里克·威尔森 Patrick Wilson 饰）与黑人女作家丽莎（凯丽·华盛顿 Kerry Washington 饰）建立了超越种族的爱情，婚后他们搬到安详宁静的“湖景水坝”，享受着甜蜜的幸福。但是他们喜悦的心情并未持续太久，马特森夫妇的邻居名叫阿贝尔?特纳（塞缪尔·杰克逊 Samuel L. Jackson 饰），是供职于洛杉矶警署的一名黑人警官。阿贝尔严厉古板，不苟言笑，而且似乎对跨种族的婚姻存有深深的敌意，也因此马特森夫妇成了他的眼中钉，肉中刺。 在此之后，阿贝尔用尽制造各种各样的麻烦，只为将马特森夫妇从社区内赶走。双方的矛盾越积越深，直至到了无法挽回的地步……
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美丽干练的玛丽·菲奥里（詹妮弗·洛佩兹 Jennifer Lopez 饰）是一名来自西西里的婚礼策划者，她凭借机敏的头脑和十二万分的热情打出一片天地，成为整个旧金山业内的佼佼者。不过，虽然经受无数的婚礼，她自己的爱情之花却迟迟未能绽放。而且此时玛丽即将迎来事业生涯中最重要的时刻，更加无暇他顾。她准备承办网络女强人弗兰·多诺利（Bridgette Wilson 饰）的婚礼，一旦成功，玛丽将有望成为老板的合伙人。 一场意外，让她邂逅了英俊帅气的医生史蒂夫·爱迪生（马修·麦康纳 Matthew McConaughey 饰），两人渐渐萌生爱意，玛丽更加坚信真爱终于降临。但是，某天她却发现，史蒂夫竟是弗兰的未婚夫。事业和爱情面前，她该如何选择？
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Recipient of the 2007 Golden Globe Award for Best Drama Television Series and multiple Emmy nominations, including Outstanding Drama Series for the past two years, "Grey's Anatomy" returns to the ABC Television Network for its fifth season. Is "happily ever after" possible for Meredith Grey and Derek "McDreamy" Shepherd? With Meredith experiencing a breakthrough in therapy - the realization that she and Derek can be extraordinary together, rather than ordinary apart -- she and Derek now face the highs and lows of being a committed couple. Continuing their first year as residents at Seattle Grace Hospital, Meredith, Cristina Yang, Izzie Stevens and Alex Karev have interns of their own to mentor, including Meredith's half-sister, Lexie Grey. Lexie has become a roommate and confidante to George O'Malley, who, after divorce with Callie, a breakup with Izzie, and learning that he failed his residency test by only one point, is striving to get both his professional and personal life back on track. After attending to his girlfriend Rebecca's mental illness on his own, and revealing that he had gone through this with his own mother, Alex finds solace in Izzie's arms. Alex must continue through this difficult time, whether or not Izzie remains by his side. Cristina, having finally won out over her tough-as-nails mentor, Erica, is back on track as a surgeon - but is there a chance for new love in her life as well? With the encouragement of Mark "McSteamy" Sloan, Dr. Callie Torres has taken a chance on love with cardiothoracic surgeon, Erica Hahn; now, she and Erica must figure out what happens after the first kiss. Overseeing the residents is the no-nonsense Chief Resident, Miranda Bailey. Facing marital troubles and the difficulty of balancing her work and personal life, Bailey has handed her responsibilities as head of the free clinic over to Izzie. Also striving for balance is Chief of Surgery, Richard Webber, who has reunited with his estranged wife, Adele. The doctors of Seattle Grace Hospital deal with life-or-death consequences on a daily basis - it's in one another that they find comfort, friendship and love. Together they're discovering that neither medicine nor relationships can be defined in black and white. Real life only comes in shades of grey. "Grey's Anatomy" stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Katherine Heigl as Isobel "Izzie" Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O'Malley, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey, and Brooke Smith as Erica Hahn.
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某晚，中央城爆发激战，闪电侠巴里·艾伦（贾斯汀·钱伯斯 Justin Chambers 配音）和超人、蝙蝠侠、戴安娜、绿灯侠等正义联盟的伙伴们与来自25世纪的急速教授及其爪牙镜子大师、陀螺、速冻队长你来我往，最终将这群恶棍绳之于法。分别时刻，急速教授的一番话触动巴里心底最敏感的地方。在此之后，似乎一切都发生变化。他一觉醒来，发现无赖帮们继续为非作歹，自己则意外丧失了变身闪电侠的能力，更令他出乎意料的是本应在童年被盗贼杀害的母亲竟然活着出现在他面前。全世界仿佛也天翻地覆，戴安娜率领的亚马逊人以及亚特兰蒂斯阴谋毁灭世界，布鲁斯死去，他的父亲托马斯·韦恩则以粗暴的蝙蝠侠身份出现。